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Understanding Sleep Mechanisms Cortistatin Well-defined receptor pharmacology (sst1-5 plus GHSR-1a) and clear mechanism of cortical synchronization make cortistatin a more tractable research target for sleep neurobiology Human Data Availability DSIP DSIP has been administered to humans in multiple studies dating to the 1980s, providing at least some clinical data

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By stimulating PDH in cancer cells to normalize glucose metabolism, it can restore their sensitivity to anoikis and weaken their metastatic potential, suggesting that PDKs are potential targets for anti-metastasis therapy (261)

Apoptosis 29:4565 Zheng X, Zhang C (2023) The regulation of ferroptosis by noncoding RNAs